Is the installed antivirus/security suite scanning the DataStore folder?
If it has been then it is possible that datastore.edb has become
Virus scanning recommendations for computers that are running Windows
Server 2003, Windows 2000, or Windows XP
*** BEFORE *** running any commands, advise you to make a Copy of
datastore.edb and move it to another location, for example, the Desktop,
*just in case * the file becomes damaged from running commands.
To do so you will have to Stop the Automatic Update service first.
Start > Run > type in
net stop wuauserv
Click OK or press Enter
Copy datastore.edb now
You can then restart the Automatic Updates service OR, leave it in the
Stopped state and run the following commands to check the Integrity of
Press enter after *each command*
Wait until the Integrity check is run [esentutl /g] and the results are
shown before entering the remaining commands.
Go to Start > Run > type in or copy and paste the below after the prompt
net stop wuauserv [ use this if you restarted the AU service ]
esentutl /g %windir%\softwaredistribution\datastore\datastore.edb
net start wuauserv [use this is you stopped the AU service above ]
Depending on what the result is there are other commands that will
attempt to Defragment, Recover, and Repair datastore.edb. if the
Integrity check indicates that they should be run.
Please post back with the result of the Integrity check.
MowGreen [MVP 2003-2008]